Interactions of the Choline And GEranate (CAGE) Deep Eutectic Solvent with Lipid Bilayers
Deep eutectic solvents (DES) are a form of ionic liquid, composed of mixtures of a salt with a neutral molecule, which are stable liquids at room temperature. They can be prepared using non-toxic components from natural sources and are of increasing interest in pharmaceutical formulations due to their low irritancy. In particular the choline and geranate (CAGE) DES has shown a remarkable ability to enhance transdermal delivery of pharmaceuticals, from small molecules to large proteins. The mechanism by which it enhances skin penetration however is not well understood, and so far few studies have focused on this. We propose to use contrast variation neutron reflectivity to undertake an initial study on how CAGE in dilute solutions interacts with a model lipid bilayer, and to compare this with a closely related but inactive species, choline octanoate. Neutron reflectivity and selective deuteration will provide the ability to locate the choline and geranate or octanoate species in the bilayers and so help to determine how CAGE can facilitate the passage of other species through the skin.
The data is currently only available to download if you are a member of the proposal team.
The recommended format for citing this dataset in a research publication is in the following format:
Karen J Edler; BROOKS Nicholas; CES OSCAR; DOBRE Ana; MICCIULLA Samantha; NEVILLE George and WELTON Tom. (2021). Interactions of the Choline And GEranate (CAGE) Deep Eutectic Solvent with Lipid Bilayers. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-927
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This data is not yet public
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