NR study of interactions between biocidal surfactants and a bacterial membrane-mimic monolayer
Quaternary ammonium compounds (QACs) are a group of cationic surfactants used as biocides in disinfectants and sanitizers for hard surface cleansing in hospitals, public hygiene and industrial food and water treatments. Although QACs are cationic surfactants with well-defined structures (charge groups, chain length and branching) and physical properties (critical micelle concentration (CMC), surface tension at CMC and solubility boundaries), there has been little effort to try to link such data to their efficacy against bacteria. The missing link lies in understanding how QACs interact with lipid membranes in the context relevant to bactericidal actions. The broad aim of this project is to establish a knowledge base at the molecular level and use such information to understand antimicrobial actions of QACs at the cellular level. With help of contrast variations NR can determine the composition of lipids and surfactants and their extent of mixing from which the structural damage to the lipid film caused by different biocide surfactants can be assessed. Such information can't be obtained by other means.
The data is currently only available to download if you are a member of the proposal team.
The recommended format for citing this dataset in a research publication is in the following format:
FOX Laura; FRAGNETO Giovanna; HOLLOWELL Peter; LI Zongyi; Jian Ren Lu; Armando Maestro and PETKOV Jordan. (2021). NR study of interactions between biocidal surfactants and a bacterial membrane-mimic monolayer. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-929
This data is not yet public
This data is not yet public
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