Is lipid exchange directly related to the apolipoprotein present in HDL? A study with ApoA1, the most abundant apolipoprotein in human serum
Atherosclerosis, resulting in cardiovascular disease, is the largest killer in the west. Low- and high-density lipoproteins play major roles in the processes involved in the development of this disease. Their involvement arises from the removal or deposition of lipids into artery walls. However, these processes are not fully understood, therefore determining the role of the particle and bilayer composition alike is of fundamental importance in the treatment of the disease. The aim of this study is to gain insight into the effect both the bilayer and the reconstituted HDL particle compositions have on the exchange rate of lipids, to help determine the specific roles of each of the components in turn.
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Sarah Waldie; CARDENAS; Yubexi Correa; FORSYTH Victor Trevor; HAERTLEIN Michael; MARIC Selma; MICCIULLA Samantha and MOULIN Martine. (2020). Is lipid exchange directly related to the apolipoprotein present in HDL? A study with ApoA1, the most abundant apolipoprotein in human serum. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-931
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