Neutron Reflection Study of the interaction of DPPC/DPPG monolayer with acyl-L-carnitine in different pH by Langmuir Trough
In the past decade, there is a rise in the disease caused by bacterial infections. As a result, there is a high demand for the antibacterial agents which can kill bacteria effectively, especially in some extreme environment. From the pre-work, we measured the CMC of C12-L-carnitine, C14-L-carnitine and C16-L-carnitine, and their MIC to several kinds of bacteria e.g. E.coli. We found that in pH 7, acyl-L-carnitines have no effect to E.coli. But when the in pH 5, acyl-L-carnitines can kill E.coli in a low concentration. This means acyl-L-carnitines have a pH-responsive antibacterial function. However, there is no direct structural evidence to study how acyl-L-carnitines interact with bacteria. Neutron reflection will examine how acyl-L-carnitine effect the membrane model of bacteria. The success of this proposal will provide constructive suggestions for further carnitine design.
The data is currently only available to download if you are a member of the proposal team.
The recommended format for citing this dataset in a research publication is in the following format:
Jian Ren Lu; LIU Huayang and Armando Maestro. (2021). Neutron Reflection Study of the interaction of DPPC/DPPG monolayer with acyl-L-carnitine in different pH by Langmuir Trough. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-935
This data is not yet public
This data is not yet public
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