Neutron Reflection Study of the interaction of DPPC/DPPG monolayer with acyl-L-carnitine in different pH by Langmuir Trough
In the past decade, there is a rise in the disease caused by bacterial infections. As a result, there is a high demand for the antibacterial agents which can kill bacteria effectively, especially in some extreme environment. From the pre-work, we measured the CMC of C12-L-carnitine, C14-L-carnitine and C16-L-carnitine, and their MIC to several kinds of bacteria e.g. E.coli. We found that in pH 7, acyl-L-carnitines have no effect to E.coli. But when the in pH 5, acyl-L-carnitines can kill E.coli in a low concentration. This means acyl-L-carnitines have a pH-responsive antibacterial function. However, there is no direct structural evidence to study how acyl-L-carnitines interact with bacteria. Neutron reflection will examine how acyl-L-carnitine effect the membrane model of bacteria. The success of this proposal will provide constructive suggestions for further carnitine design.
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Jian Ren Lu; LIU Huayang and Armando Maestro. (2021). Neutron Reflection Study of the interaction of DPPC/DPPG monolayer with acyl-L-carnitine in different pH by Langmuir Trough. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-935
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