Investigating the molecular basis of inflammatory skin conditions
The tri-layered structure of the long periodicity phase (LPP) is unique to the stratum corneum (SC) and is critical to the skin's barrier function. Small changes in the LPP composition can greatly reduce its barrier properties and can lead to inflammatory skin conditions such as atopic dermatitis and psoriasis. Some of the major pathologically relevant changes involve a decreased concentration of the ceramide nonhydroxy(N)-(tetracosanoyl)-phytosphingosine (CER NP) and an increased concentration of the ceramide N-(tetracosanoyl)-sphingosine(CER NS). Using judiciously formulated / LPP-mimicking mixtures of ceramides, free fatty acids, and cholesterol, we aim here to determine (a) the extent and nature of any differences in structure between simple and more complex LPP model systems, and (b) the effect on the structure of our more complex LPP model caused specifically by changes in the relative proportions of CER NP and CER NS. By extrapolation from these latter observations we aim to shed light on the effect of such changes in the SC of patients suffering from inflammatory skin conditions.
The data is currently only available to download if you are a member of the proposal team.
The recommended format for citing this dataset in a research publication is in the following format:
M Jayne Lawrence; BARLOW David J.; BEDDOES Charlotte; DEME Bruno; g.s.gooris and NADABAN Andreea. (2021). Investigating the molecular basis of inflammatory skin conditions. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-939
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This data is not yet public
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