Understanding the microscopic properties and drug diffusion kinetics of long-acting peptoid-peptide drug delivery implants for HIV/AIDs
Patients struggle to adhere to complex regimens of HIV medicines, which require a cocktail of drugs to be taken several times daily. Our research group aims to overcome this issues by creating a long-acting drug releasing injection to deliver HIV drugs for 28 days. This hydrogel implant, composed of biologically stable peptide-like molecules, termed peptoid-peptides, forms in response to enzymes present within the skin. This hydrogel implants has the advantage of reducing rapid drug release, to gradually deliver HIV drugs over 28 days, thereby improving patient adherence to medication and provide clinical HIV treatment/prevention. This project will explore the role of gel fibre structure and entangled gel fibre networks on both i) mechanical (gel formation, rheology, gel strength) and ii) drug release properties (drug cleavage from peptoid-peptide, drug diffusion). Small angle neutron scattering will be used to probe the properties of gel fibres. Four different peptoid-peptides will be studied, both concentration of gelator and enzyme trigger will be varied to provide SANS data that will be valuable in optimising the peptoid-peptide structure for 28 day delivery of HIV drugs.
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LAVERTY Garry; CROSS Emily and SCHWEINS Ralf. (2021). Understanding the microscopic properties and drug diffusion kinetics of long-acting peptoid-peptide drug delivery implants for HIV/AIDs. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-972
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