Caffeine permeability across lipid membranes
Passive transport of substances across a lipid membrane is a fundamental biological process with strong implications for medical and pharmaceutical applications. One of the most widely used drug active molecule, caffeine, is a perfect model to understand how purine molecules interacts, cross and accumulate with cell membranes. With this proposal we aim to characterize the kinetics of caffeine absorption in a model bilayer containing a variable amount of polar lipids, mimicking typical composition of PC and PS lipids in mammalian cell membranes. This experiment will also allow us to locate, with a sub-nanometer resolution, caffeine molecules adsorbed in the bilayer and to monitor structural changes caused by this absorption. Overall, the results will contribute to the understanding of passive transportation of drug molecules and they will show how absorption of caffeine can alter membrane properties and enhance the permeation of other small drug molecules.
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GERELLI YURI; CORUCCI Giacomo and TAVAGNACCO Letizia. (2020). Caffeine permeability across lipid membranes. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.DIR-180
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