Determination of thermoresponsive microgels and PEG-based nanoparticles form factor
We propose to measure the changes in structure of thermoresponsive PNIPAM-based microgels above (40 °C) and below (25 °C) the well-known VPT. These data are necessary to clarify some of the structural features emerged from earlier SANS experiments performed in a low-resolution configuration at the ISIS neutron source. If successful, this experiment will allow the submission of a publication within the end of the year. During the same easy access experiment we plan to investigate the internal structure of PEG-Polyamine nanoparticles developed as drug delivery systems. We have performed SAXS, DLS and TEM measurements on these samples, and by SANS we plan to determine the relative arrangement on the two polymeric components. For this purpose, NPs with deuterated PEG will be prepared. The need of an easy access is dictated by the limited number of samples to be measured.
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GERELLI YURI; DUGO Erica; PEPE Alessia and PORCAR Lionel. (2021). Determination of thermoresponsive microgels and PEG-based nanoparticles form factor. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.EASY-1060
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