Functional insertion of a self-assembling capsule into solid-supported triblock-copolymer membrane for specific guest molecule uptake
The aim of this project is to functionally insert a macromolecular hexameric capsule into a solid-supported triblock-copolymer membrane. The capsule self-assembles from resorcinarene monomers (Rs) in apolar, water-saturated solutions such as CHCl3, and is able to specifically encapsulate cationic guests in its cavity. For functional insertion, the capsule must be able to assemble inside the block-copolymer membrane and take up a guest molecule from the aqueous phase. The difficulty is the sensitivity of the capsule to polar solvents, since they lead to its disassembly. In a bulk experiment in CHCl3 solution we found that the capsule disassembles in presence of the hydrophilic polymer block, but not in presence of the hydrophobic block. We used QCM-D to deposit the hybrid polymer-Rs membranes by a solvent-assisted approach and to quantify the uptake of a cationic guest from the aqueous flow. We found homogeneous hybrid membranes (also characterised by AFM), containing functional capsules with specific guest uptake ability, proved by QCM-D and confirmed by LC-MS. Since we suspect the capsules located in the hydrophobic layer, we would like to confirm this with neutron reflectometry.
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The recommended format for citing this dataset in a research publication is in the following format:
Moritz S. Muthwill and Nicoḷ Paracini. (2023). Functional insertion of a self-assembling capsule into solid-supported triblock-copolymer membrane for specific guest molecule uptake. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.EASY-1187
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