Protein corona formation on surface-functionalized polystyrene nanoparticles
Blood proteins can actively interact with nanoparticles introduced into the body, giving rise to the formation of the “protein corona”. As a consequence, nanostructures can lose their chemical properties, leading to dramatic changes of their predesigned functionality. The magnitude of this effect depends on the nature and concentration of proteins forming the corona. Although great efforts have been made in recent years to understand the protein corona formation process, there are still significant issues that need to be addressed to design more biocompatible nanoparticles. For this reason, we aim at investigating the changes in nature and conformation of common plasma proteins interacting with polymeric nanoparticles. Also we want to evaluate the influence of different surface functionalization such as different chain length poly(ethylene glycol) (PEG) and SDS to unravel their role in the protein corona formation
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The recommended format for citing this dataset in a research publication is in the following format:
MARTINEZ NEGRO Maria and PREVOST Sylvain. (2020). Protein corona formation on surface-functionalized polystyrene nanoparticles. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.EASY-662
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This data is not yet public
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