Determination of neutron relative biological effectiveness factors for Boron Neutron Capture Therapy and test of different boron compounds b
Boron neutron capture therapy (BNCT) is an experimental form of radiotherapy based on the combined effect of the uptake of a 10B-containing compound and the irradiation with low energy neutrons. The measurements proposed in this project pursue the advance in two key research lines for improving BNCT: one is the accurate calculation of the photon equivalent dose in BNCT which is essential for the treatment planning and the second is the search of better boron compounds for the therapy. Both lines require radiobiological experimentation. In the first problem we want to improve the data on the relative biological effectiveness factors for the main dose contributions: thermal, gamma from H capture and boron dose. The PF1b line at ILL is unique for these measurements due to the high flux and the lack of gamma contamination in the beam. The second one is the study of compounds that can potentially deliver much more boron atoms to the tumor cells, which would represent a major advance for the therapeutic capability. For this purpose boron-loaded nanostructures are specially promising because they can carry a lot of boron atoms to the tumors via the enhanced permeation and retention eff
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I. Porras; ALTIERI SAVERIO; ALVAREZ RODRIGUEZ Patricia; ARIAS DE SAAVEDRA Fernando; AUZELY VELTY Rachel; BUSSER; COLL Jean Luc; ELEME Zinovia; FORSYTH Victor Trevor; GEORGALI Efstathia; KALOT Ghadir; KOESTER Ulli; PATRONIS Nikolaos; PEDROSA Maria; PORRAS QUESADA Maria Isabel; POSTUMA Ian; J. Praena; PROTTI Nicoletta; RUIZ Carmen; MJ Ruiz-Magaņa; M.P.Sabariego; SANCEY Lucie and SOLDNER Torsten. (2021). Determination of neutron relative biological effectiveness factors for Boron Neutron Capture Therapy and test of different boron compounds b. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.LTP-3-2
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