COMPLETING A NEUTRON REFLECTOMETRY STUDY OF NATIVE PULMONARY SURFACTANT INTERFACIAL FILMS AT THE HIGHEST SURFACE PRESSURES
Pulmonary surfactant is a lipid-protein complex crucial for breathing. It covers the alveolar interface in a rapid and efficient way, what is needed to prevent alveolar collapse. It is possible thanks to the accumulation of material in highly dynamic subpahse surfactant reservoirs that nurture the interface with lipids during inspiration and keep the excluded material associated to the interface during expiration. Its detailed understanding is vital for the treatment of lung pathologies and the development of new surfactant-based therapies. Usually, porcine surfactant has been used for the study of the system but recently a new surfactant isolated from human amniotic fluid has been isolated and showing the properties of a newly synthetised material. We have used neutron reflectometry to decipher the structural rearrangements occurring in this materials along respiratory mechanics still uncharacterized. Nevertheless, the most interesting experiments at the highest surface pressures (= lowest surface tensions) where most of these structural reorganizations take place still need to be performed.
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Cruz A.; Javier Carrascosa-Tejedor; COLLADA Ainhoa; GUTFREUND Philipp; Armando Maestro; ORIA LEDESMA Leyre; PENA FIGUEROA Miriam; PEREZ-GIL Jesus and P. Sánchez-Puga. (2023). COMPLETING A NEUTRON REFLECTOMETRY STUDY OF NATIVE PULMONARY SURFACTANT INTERFACIAL FILMS AT THE HIGHEST SURFACE PRESSURES. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-1004
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