Lipid exchange dynamics between native lipoprotein particles and human cell mimics
In atherosclerosis lipids and fibrous elements accumulate in the blood vessels forming plaques that eventually can lead to myocardial infarction or stroke. High and low density particles, HDL and LDL respectively, have been shown to play a role in the development and the progression of the plaque build-up and are currently used as biological markers in addition to measurements of total lipid and cholesterol. Understanding the dynamic/structure relationship of different lipoproteins and especially the mode of action with which they release or accept their lipid cargo is therefore a prerequisite for the development of better standards and methods for diagnostics of atherosclerosis and aid in the development of targeted therapies in the fight against cardiovascular disease. Here, SANS in combination with selective deuteration was used to follow the molecular lipid exchange between native lipoprotein particles and cell-membrane mimics.
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CARDENAS; Christopher J. Garvey; Dainius Jakubauskas; Tania Kjellerup Lind; PORCAR Lionel and Sarah Waldie. (2019). Lipid exchange dynamics between native lipoprotein particles and human cell mimics. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-859
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