Structural characterization of pulmonary surfactant lipid-protein interfacial films
Pulmonary Surfactant (PS) is a lipid-protein complex critical to maintaining operational breathing in mammalian lungs. It forms surface-active films at the air-liquid respiratory interface to stabilize the lungs at the end of expiration, so minimizing the work of breathing. Extensive research along the last decades has yielded a model for the mechanism by which surfactant proteins (mainly SP-B) promote the formation of complex multilayered surfactant films and how they modulate their biophysical properties for maximal stability under the demanding conditions imposed by compression-expansion breathing dynamics. However, there is still lacking a full description on the assembly of lipid-protein complexes that is crucial to fully understand the molecular mechanism by which pulmonary surfactant proteins sustain efficient respiratory mechanics and oxygen exchange in the lungs. We expect to get structural details on how surfactant proteins re-organize interfacial films, both laterally and three-dimensionally, by comparing samples obtained from natural sources with samples reconstituted upon a combination of surfactant phospholipids and surfactant proteins purified from animal sources.
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PEREZ-GIL Jesus; CASTILLO SANCHEZ Jose Carlos; COLLADA Ainhoa; Cruz A.; FRAGNETO Giovanna and Armando Maestro. (2019). Structural characterization of pulmonary surfactant lipid-protein interfacial films. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-865
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