Interaction of a recombinant version of the SARS-Cov-2 spike protein with pulmonary surfactant interfacial monolayers
COVID-19 pandemic is having a drastic impact around the world. SARS-CoV-2 is a respiratory virus belonging to the family of coronavirus and is mainly transmitted through respiratory droplets and aerosols. In such way, this virus enters the host via respiratory airways and binds to the angiotensin-converting enzyme 2 (ACE2), protein expressed by several cells in the respiratory tract, through the so-called protein spike. This infection can progress to the clinical condition known as acute respiratory distress syndrome (ARDS). Pulmonary surfactant is a complex mixture of lipid and specific proteins that constitute the first barrier to pathogens at the level of the alveolar epithelium and it is highly affected in ARDS. In this context, we propose to perform neutron reflectometry experiments in interfacial monolayers composed of pure DPPC, as model lipid, and native surfactant complexes isolated from different biological sources, exploring the effect of the incorporation of recombinant versions of the spike protein S of SARS-CoV-2. The interaction of the virus with surfactant through this protein is likely a primary event defining the fate of viral infection into the airways.
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The recommended format for citing this dataset in a research publication is in the following format:
Cruz A.; CASTILLO SANCHEZ Jose Carlos; COLLADA Ainhoa; FRAGNETO Giovanna; FRAGNETO Giovanna; Armando Maestro and PEREZ-GIL Jesus. (2021). Interaction of a recombinant version of the SARS-Cov-2 spike protein with pulmonary surfactant interfacial monolayers. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-969
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This data is not yet public
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