Completing the structural characterization of pulmonary surfactant model films by neutron reflectometry
Pulmonary surfactant is a lipid/protein complex that coats the alveolar air-liquid interface reducing the surface tension at the end of expiration. Its correct functioning is crucial for the development of breathing cycles, being otherwise alveoli at risk of collapse. As it needs to cover the interface rapidly, there are highly dynamic subpahse surfactant reservoirs that nurture the interface with lipids during inspiration and keep the excluded material associated to the interface during expiration. These lipid trafficking is possible thanks to the action of both hydrophobic proteins of the system, surfactant proteins B and C. However, their mechanism of action is still far from completely understood. This is why we used neutron reflectometry to decipher protein/lipid interactions occurring along respiratory mechanics still uncharacterized. Previous measurements on FIGARO have already provided valuable information about 3-D structures formed along respiratory dynamics. Nevertheless, the most interesting experiments at the highest surface pressures (= lowest surface tensions) where most of these structural reorganizations take place still need to be performed.
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Cruz A.; Javier Carrascosa-Tejedor; COLLADA Ainhoa; FRAGNETO Giovanna; Armando Maestro; Nicoḷ Paracini; PEREZ-GIL Jesus and P. Sánchez-Puga. (2023). Completing the structural characterization of pulmonary surfactant model films by neutron reflectometry. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-02-990
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