Neutron crystallography, small-angle neutron scattering and neutron reflectometry on a bacterial adhesin
Cholera is an ancient and deadly diarrheal disease that is caused by the pathogen Vibrio cholerae. The bacterium can easily survive in the ocean, where it binds to plankton and crustaceans. Upon ingestion of contaminated water or food, the bacteria colonize the human small intestine, where they secrete their major virulence factor, the cholera toxin. Currently, many of these processes are poorly understood. Insight into the underlying molecular mechanisms may help us to develop new medications, which are urgently needed given the increase in antibiotic resistance. This proposal targets the bacterial adhesin N-acetyl glucosamine binding protein A (GbpA) and its interaction with chitin. Methods used will be Small-Angle Neutron and X-ray Scattering, Neutron reflectometry and Neutron crystallography.
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KRENGEL Ute; Matthew P. Blakeley; Kathryn Browning; CARDENAS; COQUELLE Nicolas; Armando Maestro; MOJICA CORTES NATALIA; PREVOST Sylvain and SORENSEN Henrik Vinther. (2019). Neutron crystallography, small-angle neutron scattering and neutron reflectometry on a bacterial adhesin. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-03-988
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