Molecular bases of proteome adaptation to high pressure in extremophilic Archaea
The most accepted scenarios for the origin of life imply an origin near deep-sea hydrothermal vents, e.g. an origin under both high temperature and high hydrostatic pressure (HHP). Understanding the basis of these adaptations is essential to strengthen origin of life scenarios as well as understand life in the most extreme environments. To date, genomic studies have failed to identify the basis of the adaptation to HHP. Based on recent results, we propose that HHP affects only the protein-water interface, mimicking the impact of self-crowding or organic osmolytes, explaining the failure of genomic approaches. To circumvent this problem, we propose to characterize in details the physical impact of HHP on a set of piezophile proteins, in order to determine the amino acids responsible for the adaptation to HHP and reconstruct the evolutionary path to HHP adaptation. Thus, this project will yield important data for protein folding and the understanding of the origins of life. One of the widely accepted scenarios for the origin for life suggests it appeared near hydrothermal vents in the depth of the Archaean ocean to prevent the deleterious effects of the young sun. Thus, the first cells to appear on Earth and their constituents would have been adapted to high temperature (HT) and high hydrostatic pressure (HHP). If the routes to the adaptation to HT are starting to be better understood, adaptive strategies to HHP still remain elusive. Deciphering these routes is essential to confront the putative deep-sea origins of life and will simultaneously give information on protein folding and adaptation strategies of modern piezophiles.
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The recommended format for citing this dataset in a research publication is in the following format:
PETERS Judith; Antonino Caliņ and Phil Oger. (2020). Molecular bases of proteome adaptation to high pressure in extremophilic Archaea. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-04-876
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This data is not yet public
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