The severity in COVID19 symptoms is inversely correlated with serum cholesterol levels. Is this related to impaired function of HDL?
A recent study has shown that the severity in the COVID symptoms is inversely correlated with serum cholesterol and lipoprotein levels. The lipoprotein profile is complex in humans and vary largely among individuals. Individuals with high triglyceride and high cholesterol have lipoprotein structures that are quite distinct from healthy individuals. At the same time, the SARS-CoV-2 Spike protein was shown recently to bind cholesterol and lipoproteins. In a recent director discretion beamtime at D17, we observed clear binding of the Spike protein to cholesterol containing model membranes. Moreover, we observed differences in the reflectivities upon co-incubation with high density lipoprotein (HDL) from healthy individuals with and without spike protein at model membranes containing cholesterol. This implies that the spike protein changes the mode of HDL action and its capacity to exchange lipids. In this proposal, we aim at understanding the role of cholesterol in the membrane for the HDL-spike protein interaction as well as on the type of spike protein.
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The recommended format for citing this dataset in a research publication is in the following format:
CARDENAS; CORREA Yubexi; fieschi; FORSYTH Victor Trevor; HAERTLEIN Michael; MICCIULLA Samantha and Sarah Waldie. (2021). The severity in COVID19 symptoms is inversely correlated with serum cholesterol levels. Is this related to impaired function of HDL?. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.8-05-466
This data is not yet public
This data is not yet public
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