Mixed systems of poloxamines and TPGS for transdermal gel delivery
The development of efficient nanocarriers for drug delivery demands a careful structural characterisation in order to identify the relevant architectural parameters which lead to a measured biological response. Based on our track record in the area of polymeric surfactants, the objective of this proposal is to explore the synergy of gels of TPGS and poloxamines (Tetronics) as novel drug carriers, with modulable cargo release. The experiments pursue two well-defined objectives: i) To investigate the effect of the presence of gentramicin, naproxen and acyclovir on the structure and phase behaviour of mixed systems TPGS-poloxamine. The combination of both surfactants produces gels at physiological temperature, and the purpose is their use for the transdermal delivery of these drugs, which act respectively as antibiotic, antiviral and anti-inflammatory, having different HLB and water solubility. ii) To investigate the effect that pH has on the delivery and stability of the gels and cargo release by pH-jump TR-SANS. This involves as a first step the investigation under static conditions of the different systems.
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GONZALEZ GAITANO Gustavo; Dreiss; GRILLO Isabelle; PORCAR Lionel and PUIG RIGALL Joan. (2018). Mixed systems of poloxamines and TPGS for transdermal gel delivery. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-10-1527
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