Addressing vector-borne parasitic diseases with new drug delivery systems based on mixed polymeric micelles and gels
Leishmaniasis is a neglected tropical disease with high morbidity and mortality, considered the second leading cause of death worldwide by a parasitic agent. The available drugs exhibit high toxicity and long duration schedules that can be overcome with more efficient formulations. Our objective is to elucidate by SANS the structures formed at physiological conditions by PEO/PPO-based block copolymers (Pluronic and Tetronic) in combination with pentamidine and miltefosine (MF), an alkylphospholipid with activity against various parasite species. Due to its amphiphilic nature, MF forms mixed micelles and gels with the polymers, depending on the concentration, temperature and pH (Tetronic). The combination Tetronic-Pluronic produces also mixed micelles in which the loading capacity can be tuned by the proportion of the co-surfactants. The experiments will be conducted at the diluted and concentrated regimes, using the copolymers and their mixtures combined with both drugs. The ultimate aim is the design of drug delivery systems based on dual combination therapy in which the drugs act at lower concentration, reducing the side effects while keeping their therapeutic action.
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GONZALEZ GAITANO Gustavo; Javier Carriles; JP Fuenzalida Werner; MENCHICCHI Bianca and METILLI Lorenzo. (2025). Addressing vector-borne parasitic diseases with new drug delivery systems based on mixed polymeric micelles and gels. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-10-1883
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