Crowded Solutions of Irreversible Single-Chain Nano-Particles: Transition to Crumpled Globular Conformation at High Concentrations
Single-chain nanoparticles (SCNPs) are promising nano-objects in the nano-technology field and can be considered as good model systems for intrinsically disordered proteins. Characterizing their behavior in crowding environments is thus a highly interesting problem. In this project we aim to characterize the intramolecular conformations of SNCPs in solution, exploring a broad range of concentrations from the dilute to the concentrated regime and melt, and to establish differences with the behaviour for crowded solutions of reversible and irreversible SCNPs. We have already demostrated the insensitivity of chain conformation upon crowding for the reversible case, as predicted by our simulations. Now we want to prove the transition to crumpled globular conformation in irreversible SCNPs, as well as the transition to random coil in the linear precursor chains. The involved experiments are a clear showcase of the unique capabilities offered by high-concentration label techniques with neutron scattering.
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The recommended format for citing this dataset in a research publication is in the following format:
Arantxa Arbe; ASENJO SANZ Maria Isabel; COLMENERO Juan; MORENO Angel; POMPOSO Jose A.; PORCAR Lionel and RUIZ Ainara. (2024). Crowded Solutions of Irreversible Single-Chain Nano-Particles: Transition to Crumpled Globular Conformation at High Concentrations. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-11-2209
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This data is not yet public
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