Unravelling the mechanisms of complexation between Tetronics and cyclodextrins
Cyclodextrins (CDs), cyclic oligosaccharides consisting of 6, 7 or 8 glucopyranose units, can thread onto polymer chains and form inclusion complexes referred to as pseudopolyrotaxanes (PPR) - the starting point of versatile supramolecular constructs. These complexes have applications in drug delivery, as injectable gels and responsive molecular machines. Following-up a substantial body of work in the area of PPRs, we are focusing in this study on Tetronics, X-shaped PEO-PPO block copolymers (related to the more well-known family of Pluronics) and their complexes with a range of cyclodextrins. We propose to use time-resolved SANS experiments; combined to a stopped-flow set-up - to elucidate the mechanisms of CD threading, in particular: the early-stages of complexation, the competitive processes involved when two types of CDs are present and the impact of temperature on the complexation process.
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Dreiss; GONZALEZ GAITANO Gustavo; GRILLO Isabelle and R. Serra-Gómez. (2015). Unravelling the mechanisms of complexation between Tetronics and cyclodextrins. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-12-401
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