Understanding the interaction of single chain nanoparticles with biomimetic model membranes.
Single-chain nanoparticles (SCNPs) are ultra-small soft nano-objects formed by the intra-molecular folding of polymer chains. Amphiphilic copolymers with 2-acetoacetoxy ethyl methacrylate (AEMA) and N-isopropyl acrylamide (NIPAM) can self-fold into SCNPs with a globular structure, featuring a hydrophobic core and hydrophilic shell. These SCNPs are responsive to temperature and pH, making them promising for drug delivery. However, their interactions with biomimetic model membranes are not well understood. This study investigates P(NIPAM-co-AEMA) SCNPs (PNIPA) as drug delivery systems, focusing on their interaction with various membrane compositions to mimic real conditions and assess temperature effects. We will use neutron reflectometry (NR) to analyze the SCNPs' density profiles at solid/liquid interfaces and compare results with previous data from quartz crystal microbalance (QCM), atomic force microscopy (AFM), and NR.
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PENA FIGUEROA Miriam; ALVAREZ FERNANDEZ Alberto; Javier Carrascosa-Tejedor; Laura Cervera-Gabalda; Armando Maestro; ORIA LEDESMA Leyre and VERDE SESTO Ester. (2025). Understanding the interaction of single chain nanoparticles with biomimetic model membranes.. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-1161
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