Impact of the degree of curvature on the phase separation in lipid bilayer
The vast majority of studies published in the literature regarding the curvature of biological membranes and curvature-related phenomena are based on fluorescence microscopy techniques which, in the best cases, are limited to a spatial resolution of hundreds of nanometers and require the use of lipids chemically modified with fluorophores to enable their detection. Moreover, these give no information on the structure of such membranes. The use of partially deuterated lipids in combination with neutron reflectometry and GISANS will allow us to gain a deeper understanding of the lipid distribution and membrane structure around the nanoparticle and at the transition to the coexisting flat region. Here we will complete our previous results, in which we have studied mixtures of d-POPC and cardiolipin, the four-legged lipid, demonstrating that indeed there is curvature-induced phase separation in this system that is dependent on the presence of divalent ions, and also the structural asymmetric nature of the curved bilayer.
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The recommended format for citing this dataset in a research publication is in the following format:
CARDENAS; Claire Buchanan; GUTFREUND Philipp; KYZYMA Olena; MEHLER Filip; PORCAR Lionel and WOLFF Maximilian. (2025). Impact of the degree of curvature on the phase separation in lipid bilayer. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-1197
This data is not yet public
This data is not yet public
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