How does the ratio of good HDL to bad LDL cholesterol lipoproteins affect the interaction with model cell membranes?
Atherosclerosis and its consequent complications are the largest killers in the western world, with a death toll reaching 16.7 million deaths per year. Although many risk factors have been identified, it is well-known that various lipoprotein particles in the blood play an important role in the development and rupture of atherosclerotic plaques. Current best practise for diagnosis and further monitoring of the progress of atherosclerosis is measurement of the ratio of high (HDL) to low (LDL) density lipoproteins in the blood, with high proportions of HDL showing a protective effect on the body. In this proposal, we aim to study the effect of varying the ratio of HDL to LDL on supported lipid bilayers, covering both the ideal ratio for a healthy human and that expected for patients presenting atherosclerotic plaques.
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CARDENAS; Kathryn Browning; Tania Kjellerup Lind; LUCHINI Alessandra; Sara Malekkhaiat Häffner; MALMSTEN Martin; MARIC Selma and Sarah Waldie. (2016). How does the ratio of good HDL to bad LDL cholesterol lipoproteins affect the interaction with model cell membranes?. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-652
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