Comparing Antimicrobial Peptides and Peptoids: interactions with model lipid membranes mimicking bacteria and mammalian cells.
We aim to provide a fundamental understanding of how the peptoid strategy for stabilization of antimicrobial peptides (AMPs) affect their interaction with bacterial membranes. In particular, we will compare Indolicidin and the synthesised peptoid version of Indolicidin. In this way, we hope to clarify whether this group has potential in the design of new antibiotics. In order to achieve this, we plan to explore the peptoid interaction with supported lipid bilayers (SLBs) made of lipids with and without cholesterol to shed light on the role of cholesterol and whether cholesterol play an significant role in protecting mammalian cells from lysis of AMPs as our preliminary SAXS data suggest. By using Neutron Reflectometry and contrast variation we will be able to highlight the structural interaction with higher resolution than with SAXS alone.
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NIELSEN Josefine Eilsoe; BJOERNESTAD Victoria Ariel; CARDENAS; GERELLI YURI; håvard jenssen; LONE Abdullah; LUND Reidar; MOLCHANOVA Natalia and Sarah Waldie. (2019). Comparing Antimicrobial Peptides and Peptoids: interactions with model lipid membranes mimicking bacteria and mammalian cells.. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.9-13-809
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