Structural investigation of Curcumin/Laponite nanoparticles interacting with model Biomembranes
Curcumin (cur), a polyphenolic compound derived from the dietary spice turmeric, is a non-toxic, highly promising natural antioxidant compound with a broad spectrum of biomedical applications. Cur shows pharmacological activities such as antibacterial, antioxidant, antitumorigenic, and anticancer. It is capable of preventing DNA damage by decreasing the number of oxidative cancer-causing DNA molecules in tissue samples. With such multi-tasking properties, it suffers from the drawbacks of poor solubility and bioavailability. We have designed a new assembly of curcumin nanoparticles stabilized by Laponite particles and we will be denoting them as LCu Nanoparticles. Exploring the interaction between laponite/curcumin nanoparticles (LCu) and model membranes, specifically solid-supported lipid bilayers (SLBs), would offer valuable insights into curcumin's potential to dissociate from LCu nanoparticles and form robust interactions with cellular membranes. Such understanding could pave the way for the development of novel anticancer treatments. To date, only a limited number of studies demonstrate curcumin's capacity to influence lipid structure and disrupt cancerous cell membranes.
The data is currently only available to download if you are a member of the proposal team.
The recommended format for citing this dataset in a research publication is in the following format:
Armando Maestro; Nisha Pawar; GUTFREUND Philipp and PENA FIGUEROA Miriam. (2024). Structural investigation of Curcumin/Laponite nanoparticles interacting with model Biomembranes. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.EASY-1309
This data is not yet public
This data is not yet public
ILL has partnered with DataCite as the registration agency
for data persistent identifiers.