Study of the relaxational/vibrational dynamics of glass-forming systems of pharmaceutical interest
The carbohydrate trehalose and the alcohol glycerol, which are classified as “intermediate” in the Angell’'s strong-fragile scheme, are used as shelf-life extending additives in many labile pharmaceutical products. Since the preparation protocols used for obtaining the pharmaceutical systems affect the degree of crystallinity which plays a key role in determining the system stabilising properties and its bioprotective effectiveness, this is expected to have a significant role also in the understanding of the glycerol-trehalose mixture dynamical behaviour. With the aim to characterize the relaxational/vibrational dynamics of the trehalose/glycerol mixture at a glycerol concentration value of 2.5% by weight, we propose to collect QENS data by the IN5B spectrometer on this mixture as obtained following two different preparation protocols, i.e. damage-formed as obtained by ball-milling and melt-formed as obtained by a rapid undercooling of the melted crystal: - as a function of temperature across the glass transition temperature Tg at two different instrumental energy resolution values and - as a function of energy resolution at three temperature values above, below and at Tg.
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MIGLIARDO Federica; ANGELL C.Austin; CACCAMO Maria Teresa; ECKERT Juergen; LA TORRE Roberto; MAGAZU Salvatore and OLLIVIER Jacques. (2015). Study of the relaxational/vibrational dynamics of glass-forming systems of pharmaceutical interest. Institut Laue-Langevin (ILL) doi:10.5291/ILL-DATA.6-05-952
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